Synthesis and structure-activity relationship of aminopyrimidine IKK2 inhibitors

Alistair H Bingham; Richard J Davenport; Richard Fosbeary; Lewis Gowers; Roland L Knight; Christopher Lowe; David A Owen; David M Parry; Will R Pitt

doi:10.1016/j.bmcl.2008.04.062

Synthesis and structure-activity relationship of aminopyrimidine IKK2 inhibitors

Bioorg Med Chem Lett. 2008 Jun 15;18(12):3622-7. doi: 10.1016/j.bmcl.2008.04.062. Epub 2008 Apr 29.

Authors

Alistair H Bingham¹, Richard J Davenport, Richard Fosbeary, Lewis Gowers, Roland L Knight, Christopher Lowe, David A Owen, David M Parry, Will R Pitt

Affiliation

¹ UCB, Granta Park, Great Abington, Cambridge CB21 6GS, UK.

PMID: 18501602
DOI: 10.1016/j.bmcl.2008.04.062

Abstract

The synthesis and structure-activity relationship of a novel series of aminopyrimidines are exemplified. Results of key compounds from within this series in the E-selectin reporter cell assay are also reported.

MeSH terms

Cell Line, Tumor
Drug Evaluation, Preclinical
E-Selectin / metabolism
Enzyme Inhibitors / chemical synthesis*
Enzyme Inhibitors / chemistry
Enzyme Inhibitors / pharmacology*
Humans
I-kappa B Kinase / antagonists & inhibitors*
Models, Molecular
Molecular Structure
Pyrimidines / chemical synthesis
Pyrimidines / chemistry
Pyrimidines / pharmacology*
Stereoisomerism
Structure-Activity Relationship

Substances

E-Selectin
Enzyme Inhibitors
Pyrimidines
I-kappa B Kinase